高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

表面等离子体子共振技术用于分析手性药物与蛋白作用差异的研究

邹向宇, 周建光, 冯国栋, 张磊, 李明, 金钦汉   

  1. 吉林大学化学学院微分析仪器研究所, 吉林省光谱分析仪器工程技术研究中心, 长春 130023
  • 收稿日期:2005-11-15 修回日期:1900-01-01 出版日期:2006-09-10 发布日期:2006-09-10
  • 通讯作者: 金钦汉

Studies on the Difference Between Combination Reaction Enantiomeric Drugs
with Albumins by Using a New Home-made Surface Plasomon Resonance Sensor

ZOU Xiang-Yu, ZHOU Jian-Guang, FENG Guo-Dong, ZHANG Lei, LI Ming, JIN Qin-Han   

  1. Institute for Miniature Instrumentation, College of Chemistry, Jilin Pronince Research Center for Engineering and Technology of Spectral Instruments, Jilin University, Changchun 130023, China
  • Received:2005-11-15 Revised:1900-01-01 Online:2006-09-10 Published:2006-09-10
  • Contact: JIN Qin-Ha

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被引次数

15

摘要： 利用自行设计组装的一套以白色发光二极管为光源的新型表面等离子体子共振传感器实验装置测量了手性药物D-苯甘氨酸与L-苯甘氨酸与人血清白蛋白和鼠血清白蛋白的结合程度, 可以看到这一对手性药物与血清蛋白的结合程度的差异, 通过这种方法可以区分一对手性药物中的不同异构体. 与现在的手性分析方法比较, 这种方法具有不用标记、样品用量少、仪器易于自动化及小型化等优点.

关键词: 表面等离子共振传感器, 手性药物, 苯甘氨酸

Abstract: Based on surface plasmon resonance(SPR), a novel optical chemical sensor for distinguishing enantiomeric drugs was developed. The difference between combination reaction of enantiomeric drugs with albumins was studied by using this setup. According to these differences the enantiomeric drugs can be distinguished. This method was shown to have many advantages in comparison with traditional methods. The major ones include the elimination of labeling and screening rapidly.

Key words: Surface plasomon resonance sensor, Enantiomeric drugs, Phenylglycin

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