高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

99mTcN核标记的新型心肌灌注显像剂的研究

楚进锋1, 孔德靖2, 李彬2, 王学斌2, 陆洁2, 王金城3, 米宏志3, 赵建冬3   

  1. 1. 北京化工大学理学院, 北京100029;
    2. 北京师范大学化学系, 北京100875;
    3. 北京安贞医院核医学科, 北京100029
  • 收稿日期:2005-05-08 修回日期:1900-01-01 出版日期:2006-06-10 发布日期:2006-06-10
  • 通讯作者: 王学斌

Novel 99mTc-nitride Heterocomplexes as Potential Myocardial Perfusion Imaging Agents

CHU Jin-Feng1, KONG De-Jing2, LI Bin2, WANG Xue-Bin2*, LU Jie 2 , WANG Jin-Cheng3, MI Hong-Zhi3, ZHAO Jian-Dong3   

  1. 1. College of Science, Beijing University of Chemical Technology, Beijing
    100029, China;
    2. Department of Chemistry, Beijing Normal University, Beijing 100875, China;
    3. Department of Nuclear Medicine, Beijing Anzhen Hospital, Beijing 100029,
    China
  • Received:2005-05-08 Revised:1900-01-01 Online:2006-06-10 Published:2006-06-10
  • Contact: WANG Xue-Bin

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摘要： 通过配体交换反应制备了[99mTcN(PNP5)(DEDC)]+和[99mTcN(PNP5)(DPODC)]+两种新配合物, 其放化纯度均大于90%. 生物性能研究结果表明: 两种配合物在小鼠心肌中的初始摄取高, 肝、肺等非靶组织清除快, 靶/非靶比高, 有利于早期心肌显像. 其中, [99mTcN(PNP5)(DEDC)]+在小鼠中的性质较优, 且其在狗体内的性质接近99mTc-tetrofosmin, 有望成为一种新型心肌灌注显像剂.

关键词: 99mTcN核, 心肌灌注显像剂, 生物分布

Abstract: To develop a new potential myocardial imaging agent, [99mTcN(PNP5)(DEDC)]+ and [99mTcN(PNP5)(DPODC)]+ were prepared through ligand exchange reaction. Their radiochemical purities were over 90%. The results of biodistribution in mice indicate that they possessed a high myocardial uptake, rapid clearance from nontarget tissues and good ratios of target to nontarget. And [99mTcN(PNP5)\5(DEDC)]+ is superior. SPECT imaging in dog shows that its properties were similar to those of 99mTc-tetrofosmin. Based on its promising characters, it may be suitable for myocardial perfusion imaging.

Key words: Technetium-99m-nitride core, Myocardial perfusion imaging agent, Biodistribution

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