高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

基于乳酸和β-丙氨酸的聚酯酰胺共聚物合成及降解

周海1, 袁茂全2, 姚晋荣1, 邵正中1   

    1. 教育部聚合物分子工程重点实验室, 复旦大学高分子科学系和先进材料实验室, 上海 200433;
    2. 上海氯碱化工股份有限公司, 上海 200241
  • 收稿日期:2008-01-29 修回日期:1900-01-01 出版日期:2008-07-10 发布日期:2008-07-10
  • 通讯作者: 姚晋荣

Synthesis and Degradation of Polyesteramide Based on L-Lactic acid and β-Alanine

ZHOU Hai1, YUAN Mao-Quan2, YAO Jin-Rong1*, SHAO Zheng-Zhong1   

    1. Key Laboratory of Molecular Engineering of Polymers, Ministry of Education, Lab of Advanced Materials, Department of Macromolecular Science, Fudan University, Shanghai 200433, China;
    2. Shanghai Chlor-Alkali Chemical Co., Ltd, Shanghai 200241, China
  • Received:2008-01-29 Revised:1900-01-01 Online:2008-07-10 Published:2008-07-10
  • Contact: YAO Jin-Rong

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摘要： 采用直接熔融共缩聚方法成功地制备了L-乳酸/β-丙氨酸共聚物, 用红外光谱、核磁共振、凝胶色谱和DSC等方法对共聚物结构进行了表征; 考察了催化剂用量、投料比、聚合反应时间和反应温度等聚合条件对产物分子量及其结晶性能的影响. 实验结果表明, 采用质量分数为1.5%的亚锡复合催化剂在180 ℃下真空反应15 h为最佳聚合条件, 所得到的产物具有相对最大的分子量; 随着β-丙氨酸投料比增加, 相应共聚物的分子量明显下降. 所得到的L-乳酸/β-丙氨酸共聚物具有良好的降解性能, 聚合时间和β-丙氨酸含量对材料的结晶性能和降解性能均有较大的影响.

关键词: 聚酯酰胺, 直接熔融共聚, 亚锡复合催化剂, 生物降解材料

Abstract: Poly(L-lactic acid-co-β-alanine), a novel biodegradable polyesteramide, was produced by direct melting copolymerization with stannous chloride and p-toluenesulfonic acid as the catalyst, and characterized via FTIR, 1H NMR, 13C NMR, GPC and DSC. To optimize the copolymerization conditions, the content of catalyst, copolymerization temperature and time, as well as the feed ratio, were investigated. The results show the copolymers with a high molecular weight could be obtained from the copolymerization process conducted at 180 ℃ for 15 h with 1.5% of stannous complex catalyst under vacuum. The hydrolytic degradation test in PBS(pH=7.2, 37 ℃) indicates poly(L-lactic acid-co-β-alanine) has an excellent degradability, which could provide a potential application in the biomedical field as a drug control released material.

Key words: Polyesteramide, Direct melting copolymerization, Stannous complex catalyst, Biodegradable material

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