Stereo-effect of the Peptide Formation Reaction by N-(O,O-Diisopropyl) Phosphoryl Serine

Abstract

Abstract: The reactions between N-phosphoryl-L -or D-) serine and L-(or D-) histidine or L-(or D-) histidine methyl ester were investigated. Products of the reaction mixtures were analyzed by ion-pair reversed-phase HPLC with SDS as the ion-pairing reagent. The results showed that dipeptide serylhistidine was formed in all these reaction systems, and L-L and D-D types of serylhistidine were yielded in an amount about four times as much as that of the L-D and D-L type dipeptide.

Key words: Chirality, N-( O,O-diisopropyl) phosphoryl serine, Ion-paired RP-HPLC, Serylhistidine, Stereoselectivity

CLC Number:

O621

TrendMD:

HU Jian-Jun, JU Yong, ZHAO Yu-Fen . Stereo-effect of the Peptide Formation Reaction by N-(O,O-Diisopropyl) Phosphoryl Serine[J]. Chem. J. Chinese Universities, 2001, 22(3): 399.

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Stereo-effect of the Peptide Formation Reaction by N-(O,O-Diisopropyl) Phosphoryl Serine

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