Synthesis of Nicotinoyl Disubstituted Pseudo-cyclopeptide and Its Coordination Behavior with Cu2+

Abstract

Abstract: A 26-membered nicotinoyl disubstituted cyclopseudopeptide was synthesized through a simple six-step prvcedure(Scheme 1) with cystine dimethyl ester, iminodiacetic acid, and nicotinoyl chloride hy-drochloride as the starting materials. The structure of the key intermediates 4 and 5 was verified by ¹HNMR and FAB-MS, and that of the final product 7 by ¹HNMR, IR, FAB-MS and elemental analysis. Subsequent treatment of 7 with Cu(ClO₄)₂gives a mononuclear cuprate(Ⅱ) complex whose structure was characterized by IR, FAB-MS. The quick formation of the cuprate-cyclopeptide complex demonstrates that the title peptide can serve as a good reception in Cu(Ⅱ) recognition.

Key words: Pseudo-cyclopeptide, Nicotinoyl, Copper(Ⅱ) complex

CLC Number:

O625

TrendMD:

GUO Wei, WANG Jing, HE Jia-Qi, XIA Zhi-Zhong, CHENG Jin-Pei. Synthesis of Nicotinoyl Disubstituted Pseudo-cyclopeptide and Its Coordination Behavior with Cu²⁺[J]. Chem. J. Chinese Universities, 2003, 24(5): 837.

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Synthesis of Nicotinoyl Disubstituted Pseudo-cyclopeptide and Its Coordination Behavior with Cu²⁺

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