On-line Detection of Volatile Sulfur Compounds in Breath Gas by Proton Transfer Reaction Mass Spectrometry†

doi:10.7503/cjcu20140794

Chem. J. Chinese Universities ›› 2015, Vol. 36 ›› Issue (2): 236.doi: 10.7503/cjcu20140794

• Analytical Chemistry • Previous Articles Next Articles

On-line Detection of Volatile Sulfur Compounds in Breath Gas by Proton Transfer Reaction Mass Spectrometry^†

SHEN Chengyin¹, WANG Hongmei², HUANG Chaoqun¹, LU Yan¹, XIA Lei¹, CHEN Xiaojing¹, WANG Hongzhi^1,^*(), CHU Yannan^1,^*()

1. Center of Medical Physics and Technology & Cancer Hospital, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China
2. Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, China

Received:2014-09-02 Online:2015-02-10 Published:2015-01-15
Contact: WANG Hongzhi,CHU Yannan E-mail:wanghz@hfcas.ac.cn;ychu@aiofm.ac.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.21107112), the Knowledge Innovation Program of the Chinese Academy of Sciences(No KGCX-YW-917), the Anhui Provincial Program for Science and Technology Development, China(No.1301042095) and the Innovative Program of Development Foundation of Hefei Center of Physical Science and Technology, China(Nos.2012FXCX009, 2014FXCX007)

Abstract

Abstract:

To develop a kind of noninvasive method of breath diagnosis in diseases, much attention has been paid to the study of the relation between diseases and volatile organic compounds in human breath gas. However, the gas in oral cavity was usually ignored in many studies of breath gas. The bad breath odor of a participant was studied by a home-made proton transfer reaction mass spectrometer(PTR-MS). The breath via the mouth, breath via the nose and the air in the mouth cavity were monitored with the mode of multiple ion detect scans. The results show that three different volatile sulfur compounds that cause bad breath odor should be attributed to different sources. The source of methyl mercaptan in breath is oral cavity, and the source of hydrogen sulphide and dimethylsulfide in breath is lung or respiratory tract. The related result is very important to sampling and detection of breath gas.

Key words: Breath gas, Volatile sulfur compound, Proton transfer reaction mass spectrometry, Volatile organic compound, On-line detection

CLC Number:

O657.63
O659

TrendMD:

SHEN Chengyin, WANG Hongmei, HUANG Chaoqun, LU Yan, XIA Lei, CHEN Xiaojing, WANG Hongzhi, CHU Yannan. On-line Detection of Volatile Sulfur Compounds in Breath Gas by Proton Transfer Reaction Mass Spectrometry^†[J]. Chem. J. Chinese Universities, 2015, 36(2): 236.

Figures/Tables 4

Fig.1 Schematic diagram of the sampling of breath via the mouth(A), breath via the nose(B) and the air in the mouth cavity(C)

Fig.2 Monitoring VOCs of breath via mouth by PTR-MS (A) Three kinds of VOCs from five mouth breathings; (B) two kinds of VOCs from the second mouth breathing in (A).

Fig.3 Monitoring result of VOCs from mouth breathing, nose breathing and the gas in oral cavity Monitored ions at m/z 21, 42, 49 and 59.

Fig.4 Monitoring result of VOCs from mouth breathing, nose breathing and the gas in oral cavity Monitored ions at m/z 35 and 63.

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On-line Detection of Volatile Sulfur Compounds in Breath Gas by Proton Transfer Reaction Mass Spectrometry^†

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