Chem. J. Chinese Universities
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LI Yao-Wu, ZHOU You-Jun, ZHU Ju, ZHENG Can-Hui, ZHANG Min, SHENG Chun-Quan, CHEN Jun, L<SPAN lang=EN-US style=
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Abstract: Multi-copy simultaneous search(MCSS) was used to analyze the maps of four kinds functional groups(the hydrophobic, hydrophilic, positive charge and negative charge functionalities) in the taxol-binding site of the β-tubulin. Based on the result, the hydrophobic groups were distributed above Phe270, and thenamong Asp26, Glu27, Val23 and Pro358. While the hydrophilic functionalities scattered around the hydroxyl of Glu22, Asp224 and Asp26 and beneath the guanidyls of Arg276 and Arg282. The positive charge functionalities were around the carboxyl of Asp224, Asp26 and Glu22, and the hydroxyl of Gln278. The negative charge ones were beneath the guanidyl of Arg276 and Arg282, and between the sidechains of His22 and Leu228.
Key words: Microtubule, Multi-copy simultaneous search(MCSS), Anticancer agent, Computer-assistant drug design(CADD)
CLC Number:
O62
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LI Yao-Wu, ZHOU You-Jun, ZHU Ju, ZHENG Can-Hui, ZHANG Min, SHENG Chun-Quan, CHEN Jun, L<SPAN lang=EN-US style=. Property Analysis of Taxol-binding Site in β-Tubulin[J]. Chem. J. Chinese Universities, doi: .
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URL: http://www.cjcu.jlu.edu.cn/EN/
http://www.cjcu.jlu.edu.cn/EN/Y2006/V27/I11/2084
