Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (7): 1309.

• Articles • Previous Articles     Next Articles

Synthesis of Novel β-Double-bridged Porphyrin Dimers and Their Photosensitive Activity Investigation

HUANG Qi-Mao, LI Zhi-Yuan, PAN Wei, PAN Zhi-Quan*, DENG Peng-Xing, XIAO Xin   

  1. Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430073, China
  • Received:2009-11-09 Online:2010-07-10 Published:2010-07-10
  • Contact: PAN Zhi-Quan. E-mail: huangqim@163.com
  • Supported by:

    国家自然科学基金(批准号: 20471045)和湖北省自然科学基金青年杰出人才项目(批准号: 2008CDB072)资助.

Abstract:

Four novel β-double-bridged porphyrin dimers were designed and synthesized for the purpose of their photosensitivity and structure-activity relationship study. Their structures were characterized by UV, 1H NMR, IR, MS and elementary analysis. The ability of singlet oxygen production for the porphyrin dimmers under photo irradiation were determined with DPBF as the quencher. Its photosensitive cleavage ability to pBR322 plasmid DNA has been tested by gel electrophoresis. The interaction of the porphyrin dimer with CT DNA was detected by UV-Vis spectroscopy. The results showed that novel β-double-bridged porphyrin dimers exhibit obvious photosensitive cleavage activity on DNA, resulting from its well binding effects, which is better than that of β-single-bridged porphyrin dimer correspondly.

Key words: Double-bridged porphyrin dimer; DNA; Photosensitive activity

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