Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (6): 1093.

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Porous Hydroxyapatite Nanoparticles as a Carrier of Ascorbic Acid

SHAO Feng-Wei, CAI Yu-Rong, YAO Ju-Ming*   

  1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, China

  • Received:2009-11-05 Online:2010-06-10 Published:2010-06-10
  • Contact: YAO Ju-Ming. E-mail: yaoj@zstu.edu.cn
  • Supported by:

    长江学者和创新团队发展计划(批准号: IRT0654), 新世纪优秀人才支持计划(批准号: NCET070763)和钱江人才计划(批准号: 2008R10006)资助.

Abstract:

Hydroxyapatite(HAP) is the most important ceramic material for biomedical applications for drug carrier and bone fillers because of its similarity to the biominerals in bone and hard tissues in mammals. It is one of few materials that are classed as bioactive, meaning that it will support bone ingrowth and osseointegration when used in orthopaedic applications. In this work, HAP nanoparticles were fabricated by chemical co-precipitation method with the assistant of the ultrasonic treatment in the present of ascorbic acid(AA). The as-prepared HAP nanoparticles were characterized by TEM, nitrogen adsorption, XRD, FTIR and ultraviolet spectrophotometer. The results showed that the porous HAP nanoparticles were obtained, which had an average diameter of about 140 nm and an average pore diameter of about 15 nm. The porous particles could load AA and the release speed of AA could be controlled by the ultrasonic treatment with different powers. This work indicated that the porous HAP nanoparticle was a promising candidate for drug carrier.

Key words: Drug carrier; Hydroxyapatite; Ascorbic acid; Controlled release

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