Abstract:

In this study, As₂O₃-MgFe₂O₄ magnetic nanoparticles(As₂O₃-MNPs) were prepared by solvent-displacement method, and their characterization were studied by energy spectrum analysis, IR spectrum analysis and differential scanning calorimetry method(DSC). To guide the external magnetic field in the liver, the tissue pharmacokinetics of As₂O₃ in mice were also studied. The IR spectrum analysis indicats that there was MgFe₂O₄ in the As₂O₃-MNPs. The DSC results show that there was no interaction among As₂O₃, polylactic-glycolic acid(PLGA) and ferrite. The energy spectrum analysis indicates that MgFe₂O₄ and As₂O₃ were not adsorbed on the surface of MNPs but encapsulated in them. The As₂O₃ MNPs showed good magnetic targeting properties at pharmacokinetics in vivo. The liver tissue concentration-time area under the curve(AUC), peak concentration(c_max), the elimination half-time(t_1/2) of the As₂O₃-MNPs in magnetic group were significantly greater than those in the other group respectively(all P<0.05). So the magnetic targeting effect of As₂O₃-MNPs was good. As a result, the As₂O₃-MNPs are promising in chemotherapy of tumor owing to their good stability and magnetic response propertie.

Key words: As2O3 ; Magnetic nanoparticles; Tissue pharmacokinetics