Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (5): 1045.

• Articles • Previous Articles     Next Articles

Monte Carlo Simulation Study on Scaling Behavior in Growth of Antibody-antigen Complexes

WANG Hai-Jun1,3,4*, ZHANG Ping1,2,4, BA Xin-Wu1,3,4   

  1. 1. College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China;
    2. Institute of Biomedical Engineering, Chengde Medical College, Chengde 067000, China;
    3. Key Laboratory of Medical Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding 071002, China;
    4. International Center for Materials Physics, Chinese Academy of Sciences, Shenyang 110016, China
  • Received:2009-08-17 Online:2010-05-10 Published:2010-05-10
  • Contact: WANG Hai-Jun. E-mail: whj@mail.hbu.cn
  • Supported by:

    国家自然科学基金(批准号: 20873035, 20574016)资助.

Abstract:

The scaling behavior concerning the growth of antibody-antigen complexes was studied by the me-thod of Monte Carlo simulation. The validity of the algorithm we used is demonstrated by the excellent agreement between analytical results and those of Monte Carlo simulation under the case of equal reactivity. For both cases of equal and unequal reactivities, the scaling exponents of the size distribution, the weight-average binding degrees, and the characteristic correlation length are obtained, and then the scaling law on the sol-gel transition is checked. It is shown that the effects of unequal reactivity on the growth of antibody-antigen complexes are significant, and this can provide some useful information for the clinic analysis of immunoreactions.

Key words: Antibody-antigen complex; Scaling behavior; Sol-gel phase transition; Monte Carlo simulation

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