Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (4): 731.

• Articles • Previous Articles     Next Articles

Indole Alkaloids from the Leaves of Rauvolfia yunnanensis

GENG Chang-An1,2, LIU Xi-Kui1*   

  1. 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China;
    2. Graduate School of the Chinese Academy of Science, Beijing 100049, China
  • Received:2009-05-05 Online:2010-04-10 Published:2010-04-10
  • Contact: LIU Xi-Kui. E-mail: liuxikui@mail.kib.ac.cn
  • Supported by:

    云南省自然科学基金(批准号: 2006C0010Z)资助.

Abstract:

Rauvolfia yunnanensis Tsiang are commonly used as a folklore herb to treat hypertension, snake bites, and insanity in the southwest of China, and an important industrial raw material of reserpine and vertical. But the wild resources of it reduced gradually in recent years, thus we have introduced and cultivated it to the arid-hot valley region of Yunnan Province, China, and investigated the chemical constituents variety of it for the sustainable utilization. The dried leaves powder(8.0 kg) of R. yunnanensis was extracted with 95%(volume fraction) EtOH(40 L×5 , 8 h each), and led to the isolation of eleven indole alkaloids by column chromatography(silica, alumina and Sephadex LH-20 gel) methods. Their structures were identified as caberine(1), 19-ethoxyl-1-demethyl-Δ1-17-acetylajmaline(2), vellosimine(3), β-yohimbine(4), yohimbine(5), vinorine(6), picrinine(7), nareline(8), akuammicine(9), strictamine(10), reserpine(11) by spectral analysis(UV, IR, MS and 1D, 2D NMR), respectively. Among them, compound 2 was a new indole alkaloids, compounds 1, 8 and 9 were firstly isolated from this plant.

Key words: Rauvolfia yunnanensis; Indole alkaloid; 19-Ethoxyl-1-demethyl-Δ1-17-acetylajmaline; Caberine; Reserpine; Yohimbine

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