NMR-based Metabonomics Study on Serum and Urine of Hyperthyroidism

Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (2): 279.

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NMR-based Metabonomics Study on Serum and Urine of Hyperthyroidism

WEI Yang-Yang^1,2, WANG Cai-Hong³, LI Wei², DONG Ji-Yang^2*, CHEN Zhong^1,2

1. Department of Biomaterials, College of Materials,
2. Fujian Key Laboratory of Plasma and Magnetic Resonance, Department of Physics, School of Physics and Mechanical & Electrical Engineering, Xiamen University, Xiamen 361005, China;
3. Department of Endocrinology, Xiamen First Hospital, Xiamen University, Xiamen 361002, China

Received:2009-04-14 Online:2010-02-10 Published:2010-02-10
Contact: DONG Ji-Yang. E-mail: jydong@xmu.edu.cn
Supported by:
卫生部科学研究基金-福建省卫生教育联合攻关计划项目(批准号: WKJ2008-2-36)和福建省自然科学基金(批准号: 2009J01299)资助.

Abstract

Abstract:

Nuclear magnetic resonance(NMR) based metabonomics was applied to study the hyperthyroidism by analyzing metabolic profiling of serum and urine. The purpose of this study is to determine an array of characteristic metabolites in serum and urine samples from hyperthyroidism patients and then to interpret these metabolites in possible metabolic pathway. Serum samples from 33 hyperthyroidism patients together with 17 healthy volunteers and urine samples from 53 hyperthyroidism patients with 58 healthy volunteers were collected. Differences in endogenous metabolites were detected on serum and urine samples from the hyperthyroidism group and control group using multivariate statistical analysis. The results show that the hyperthyroidism group has elevated levels of choline, glucose and declined levels of VLDL, LDL, cholesterol, lactate, glycoprotein and alanine in serum samples relative to the healthy group. In urine samples, the hyperthyroidism group show increased levels of glucose, citrate, taurine and creatinine as well as decreased levels of hippurate, trimethylamine-N-oxide, formate and succinate. These results indicate that hyperthyroidism have not only disturbed the carbohydrate metabolism, lipid metabolism and protein metabolism but also influenced energy metabolism, hepatoenteral circulation and gut microflora and caused liver and kidney injury.

Key words: NMR-based metabonomics; Hyperthyroidism; Biofluid; Principle component analysis

TrendMD:

WEI Yang-Yang, WANG Cai-Hong, LI Wei, DONG Ji-Yang*, CHEN Zhong. NMR-based Metabonomics Study on Serum and Urine of Hyperthyroidism[J]. Chem. J. Chinese Universities, 2010, 31(2): 279.

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NMR-based Metabonomics Study on Serum and Urine of Hyperthyroidism

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