CJCU

Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (2): 253.

• Articles • Previous Articles     Next Articles

Investigation of the Stability and Biocompatibility of HA/ZrO2 Nanocomposite Coatings Prepared by Pulsed Electrochemical Deposition

WANG Ying-Bo, LU Xiong*, FENG Bo, QU Shu-Xin, WENG Jie   

  1. Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
  • Received:2009-02-16 Online:2010-02-10 Published:2010-02-10
  • Contact: LU Xiong. E-mail: luxiong_2004@163.com
  • Supported by:

    国家自然科学基金(批准号: 30700172)、高等学校博士学科点专项科研(新教师)基金(批准号: 20070613019)和国家科技支撑计划项目(批准号: 2006BAI16B01)资助.

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Abstract:

The dense and uniform HA/ZrO2 composite coatings were fabricated on titanium substrates by pulsed electrochemical deposition. The composition, morphologies, biocompatibility and physiological stability of the composite coatings were studied. X-ray diffraction showed Ca8(PO4)4(HPO4)2·5H2O in the coating was converted into hydroxylapatite(HA) and the coating was composed of HA and ZrO2 after heat treatments. Scanning electron microscopy(SEM) indicated that ZrO2 was uniformly distributed in the coatings and the coatings became dense after heat treatments. Atomic absorption spectrometry analysis was used to measure Ca2+ release rate of the coatings immersed in PBS. It was found that the Ca2+ release rate of HA/ZrO2 was lower than that of pure HA coatings. Nanoscratching testing revealed that HA/ZrO2 coatings had better interfacial bonding strength than that of pure HA coatings. Osteoblasts were cultured on the coatings to evaluated the biocompatibility of coatings. The results of the Alamar Blue and ALP test indicated that the composite coatings could favor the proliferation and differentiation of the osteoblasts. In summary, the as-prepared nanocomposite coatings have good biocompatibility.

Key words: HA/ZrO2 composite coating; Pulsed electrochemical deposition; Stability; Biocompatibility

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