Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (11): 2291.

• Articles • Previous Articles     Next Articles

Synthesis and Controlled Drug Release of Amphiphilic Graft Copolymers PEO-b-PGL-g-PCL

MAO Jing1,2, GAN Zhi-Hua1*   

  1. 1. Institute of Chemistry, Chinese Academy of Sciences(CAS), Beijing 100190, China;
    2. Graduate University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2009-04-21 Online:2009-11-10 Published:2009-11-10
  • Contact: GAN Zhi-Hua. E-mail: zhgan@iccas.ac.cn
  • Supported by:

    国家自然科学基金(批准号: 50830103, 50521302)资助.

Abstract:

Water-soluble diblock copolymers PEO-b-PGL with well controlled composition were synthesized by sequential anionic ring-opening copolymerization of ethylene oxide(EO) and glycidol(GL). ε-Caprolactone(CL) was further initiated by the pendant hydroxyl group of each GL unit in PEO-b-PGL copolymer to synthesize amphiphilic graft copolymers PEO-b-PGL-g-PCL with well defined grafting architecture. The self-assembly behavior of PEO-b-PGL-g-PCL graft copolymers was investigated with pyrene as a probe for the determination of critical micelle concentrations(cmc). Meanwhile, doxorubicin as a model drug was encapsulated into PEO-b-PGL-g-PCL micelles, and its release behavior controlled by diffusion and enzymatic degradation was stu-died. The influences of composition and grafting structure in PEO-b-PGL-g-PCL copolymers on self-assembly, drug loading and release were discussed.

Key words: Amphiphilic graft copolymer; Poly(ethylene oxide); Poly(ε-caprolactone); Self-assembly; Drug release

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