Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (11): 2123.

• Articles • Previous Articles     Next Articles

Damaging Effects of Photoexcited TiO2 Nanoparticles on Gastric Cancer SGC-7901 Cells

XIA Chun-Hui1,2, YU Wen-Xue1*, WANG Bai-Qi3, WANG Yu2, WANG Lu2, HUANG Hai-Tao2   

  1. 1. College of Materials Science and Engineering, Jilin University, Changchun 130012, China;
    2. Pharmacy Department, Qiqihaer Medical College, Qiqihaer 161006, China;
    3. School of Public Health, Tianjin Medical University, Tianjin 300070, China
  • Received:2009-03-04 Online:2009-11-10 Published:2009-11-10
  • Contact: YU Wen-Xue. E-mail: yuwenxue@jlu.edu.cn
  • Supported by:

    黑龙江省自然科学基金(批准号: D2007-113, D2007-114)、黑龙江省普通高等学校骨干教师创新能力资助计划(批准号: 1055G066, 1154G01)和黑龙江省卫生厅科学技术项目(批准号: 2006-414)资助.

Abstract:

Damaging effects of photoexcited TiO2 nanoparticles on gastric cancer SGC-7901 cells were investigated. The influences of nanosized TiO2 content, and irradiation time on cancer inhibition were systematically studied, and the inhibition mechanism was primarily discussed. The results demonstrate that photoexcited TiO2 nanoparticles exhibit good inhibition effects on gastric cancer SGC-7901 cells, and this process follows appro-ximately first-order reaction rule. While the concentration of TiO2 nanoparticles is about 300 μg/mL, the damaging effects are rather remarkable. In addition, the exhibition forms of gastric cancer SGC-7901 cells are apoptosis and necrosis in killing experiments. Taken together, damaging effects of photoexcited TiO2 nanoparticles on gastric cancer SGC-7901 cells might be attributed to the reactive oxygen species formed on the TiO2 nanoparticles surface.

Key words: TiO2 nanoparticle; Gastric cancer SGC-7901 cell; Photoexcitement; Damaging effect

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