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Novel 99mTc-nitride Heterocomplexes as Potential Myocardial Perfusion Imaging Agents

CHU Jin-Feng1, KONG De-Jing2, LI Bin2, WANG Xue-Bin2*, LU Jie 2 , WANG Jin-Cheng3, MI Hong-Zhi3, ZHAO Jian-Dong3   

  1. 1. College of Science, Beijing University of Chemical Technology, Beijing
    100029, China;
    2. Department of Chemistry, Beijing Normal University, Beijing 100875, China;
    3. Department of Nuclear Medicine, Beijing Anzhen Hospital, Beijing 100029,
    China
  • Received:2005-05-08 Revised:1900-01-01 Online:2006-06-10 Published:2006-06-10
  • Contact: WANG Xue-Bin

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Abstract: To develop a new potential myocardial imaging agent, [99mTcN(PNP5)(DEDC)]+ and [99mTcN(PNP5)(DPODC)]+ were prepared through ligand exchange reaction. Their radiochemical purities were over 90%. The results of biodistribution in mice indicate that they possessed a high myocardial uptake, rapid clearance from nontarget tissues and good ratios of target to nontarget. And [99mTcN(PNP5)\5(DEDC)]+ is superior. SPECT imaging in dog shows that its properties were similar to those of 99mTc-tetrofosmin. Based on its promising characters, it may be suitable for myocardial perfusion imaging.

Key words: Technetium-99m-nitride core, Myocardial perfusion imaging agent, Biodistribution

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