Synthesis of Amphiphilic Dimers of Gd(Ⅲ) Complexes and Their Liver-selective Contrast Enhancement in MRI

Abstract

Abstract: Benzyl ester of L-lysine was bis-acylated with diethylenetriaminepentaacetic monoanhydride(DTPA-MA) and ethylenediaminetetraacetic monoanhydride(EDTA-MA) respectively to produce two dimeric ligands. The reactions of these two ligands with GdCl₃·6H₂O yield amphiphilic bi-nuclear Gd(Ⅲ) complexes. These new ligands and their respective Gd(Ⅲ) complexes were characterized by IR, ¹HNMR and elemental analysis. The dimeric complexes show higher relaxivities as compared to that of Complex Gd-DTPA which is widely used in clinic diagnoses. The Gd(Ⅲ) complex with bis-diethylenetriaminepentaacetate of benzyl ester of lysine(Gd₂·3_a) exhibits no obvious toxicity and offers a higher MRI signal enhancement as well as longer retention time in the t₁-weighted imaging of Wistar rat liver tissue compared to complex Gd-DTPA.

Key words: Amphiphilicity, Dimeric contrast agent, Dimer-Gd(Ⅲ) complex, Relaxivity, Liver-selective MRI, Contrast enhancement

CLC Number:

O614.33/O657.61

TrendMD:

ZHOU Jin-Lan, WAN Fu-Xian, YU Kai-Chao, DING Shang-Wu . Synthesis of Amphiphilic Dimers of Gd(Ⅲ) Complexes and Their Liver-selective Contrast Enhancement in MRI[J]. Chem. J. Chinese Universities, 2005, 26(8): 1391.

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Synthesis of Amphiphilic Dimers of Gd(Ⅲ) Complexes and Their Liver-selective Contrast Enhancement in MRI

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