Chem. J. Chinese Universities ›› 2003, Vol. 24 ›› Issue (2): 265.
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WANG Lan-Ying, HU Zhi-Biao, SHI Zhen
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Abstract: Eight 1,3-dimethyl-2-alkyl ethenyl substituted benzimidazolium salts which were used as the models of N5, N10-C+R-tetrahydrofolate(THF) coenzymes at formic acid oxidation level were synthesized by the reaction of o-phenylenediamine with acetic acid giving 2-methyl benzimidazole, and the consecutive reaction with methyl iodide and aldehydes. Their molecular structures were characterized by elemental analysis, 1HNMR, IR, MS and UV-Vis spectra. These model compounds can react with nucleophilic reagents(Grignard reagents) to give alkyl ethenyl substituted one carbon unit transfer products α,β-unsaturated ketones. A convenient biomimetic method for synthesis of α,β-unsaturated ketones was provided.
Key words: Tetrahydrofolate, Coenzyme model, Benzimidazolium salt, α,β-Unsaturated ketones
CLC Number:
O626
TrendMD:
WANG Lan-Ying, HU Zhi-Biao, SHI Zhen. Synthesis and Carbon Unit Transfer Reactions of Ethenyl Substituted N5, N10-C+R-tetrahydrofolate Coenzymes[J]. Chem. J. Chinese Universities, 2003, 24(2): 265.
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http://www.cjcu.jlu.edu.cn/EN/Y2003/V24/I2/265