CJCU

Chem. J. Chinese Universities ›› 2003, Vol. 24 ›› Issue (1): 73.

• Preface • Previous Articles     Next Articles

A Kinetic NMR Study of Reduction Mechanism of NADH Models

LI Jing1, LIU You-Cheng1,3, WU Sai-Yu2, XIA Jing-Jing1, ZHANG Jia-Hai2, WU Ji-Hui2   

  1. 1. Department of Chemistry;
    2. Department of Biology, University of Science and Technology of China, Hefei 230026, China;
    3. National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
  • Received:2001-10-29 Online:2003-01-24 Published:2003-01-24

PDF (PC)

Abstract: The rate constant and kinetic isotopic effect(kH/kD) of the reduction of 2-bromo-1-phenylethylidenemalononitrile with NADH model were determined through NMR spectroscopy. The results were consistent with that the hydride transfer step of the reaction which was the rate-determining step, and were comparable to the results obtained through UV-Vis Spectroscopy reported previously.

Key words: NADH models, Kinetic NMR, Hydride transfer

CLC Number: 

TrendMD: