Abstract: The enantioselective total synthesis of 12-carboxyeudesma-3, 11(13)-diene(1) was achieved starting from(-)-dihydrocarvone in ten steps for the first time. The key steps mainly include the introduction of hydroxyl group into C-12 position of eudesmane by Vilsmeier chlorination and the generation of C3-C4 double bond into the eudesmane skeleton by elimination of halide.

Key words: 12-Carboxyeudesma-3,11(13)-diene, Enantioselective total synthesis, (-)-Dihydrocarvone