Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (S1): 449.
• Synthetic Sciences • Previous Articles Next Articles
HUI Xin-Ping1, ZHANG Yan1, GUAN Zuo-Wu2, ZHANG Zi-Yi1
Online:
Published:
Abstract:
Cephalosporin derivatives are an interesting class of β-lactam antibiotics because of their power against a large number of both Gram-positive and Gram-negative organisms. Many efforts have been made to synthesize cephalosporin by varying the substituents. Further pharmacological research indicated the inhibitory activity, broad-spectrum biological activity and β-lactamase resistance determined by the side chain at 7β position of 7-ACA and the structure of substituted group at C3 position. Actually, most of its applications in clinic are the derivatives linked with heterocyclic at C3 and 7β position of cephalosporin skeleton. Literature[1] also revealed that cephalosporin containing aminothiazoloxime at the 7β position of 7-ACA used as antibiotics with obvious applications. Moreover, some compounds bearing 1,2,3-triazole ring at the C3 position of 7-ACA have been reported to possess better antibacterial activity. For these purpose, we synthesized new cephalosporin 3a-c and 5a-c by the reaction of 7-ACA with 2-arylamino-1,3,4-thiadiazol-5-thioles, and then reacted with 1 -aryl-5-methyl-1H-1,2,3-triazol-4-formyl chloride 2 or aminothiazoloxime active ester 4,respectively.
TrendMD:
HUI Xin-Ping, ZHANG Yan, GUAN Zuo-Wu, ZHANG Zi-Yi. Synthesis and Antibacterial Activities of 7 β-Heterocyclyl-3-(2-substituted 1,3,4-thiadiazol-5-thiometbyl)Cephalosporin[J]. Chem. J. Chinese Universities, 2000, 21(S1): 449.
0 / / Recommend
Add to citation manager EndNote|Ris|BibTeX
URL: http://www.cjcu.jlu.edu.cn/EN/
http://www.cjcu.jlu.edu.cn/EN/Y2000/V21/IS1/449