Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (S1): 437.
• Synthetic Sciences • Previous Articles Next Articles
LEE Sang-Ku, ZHAO Zu-Chun
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Halichlorine and Pinnaic acid are two novel marine natural products isolated from a Japanese sponge, and an Okinawan bivalve respectively. The unique azaspirl[4.5]decane-core structure prexent in both compounds provides a synthetic challenge, Herein, we describe a synthetic approach to the azaspiro[4.5]decane-core structure through an intramolecular[3+2] cycloaddition followed by an intra-molecular Michael addition and in situ isomerization to afford the azaspirocyclic core structures stereospecifically in 10 steps with 40% overall yield. Alternatively, the same core structure was achieved by tandem cycloaddition and isomerization approach.
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LEE Sang-Ku, ZHAO Zu-Chun(spring). Synthetic Studies on Halichlorine and Pinnaic Acid. Stereospecific Preparation of the Azaspiro Core Structure[J]. Chem. J. Chinese Universities, 2000, 21(S1): 437.
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http://www.cjcu.jlu.edu.cn/EN/Y2000/V21/IS1/437