Studies of Quinazolone Analogues Containing Phosphorus and Their Reaction with Aldehydes

Abstract

Abstract: Aseries of 1-methoxycarbonylmethyl 2-(1-substituted hydroxymethyl) 3-benzyl 2,4-dioxo-1,3,2-benzodiazaphosphorins 2 or Ò and their rearrangement reaction products 3 or Ó have been synthesized by the reaction of aldehydes and P_Hreagent. Their structures were confirmed by elemental analysis, NMR, IRand MS. On the basis of NMRanalyses, we studied the diastereoisomerism phenomenon of the products 2 or Ò and the rearrangement reaction by which the products 3 or Ó were formed. The results of preliminary bioassay show that some of the target compounds have good in vitro activity against HSV-1 and (or) excellent fungicidal activity.

Key words: Quinazolone analogues containing phosphorus, Diastereoisomerism, Rearrangement reaction, Biological activity

CLC Number:

O626

TrendMD:

HUANG Jun-Min, CHEN Ru-Yu . Studies of Quinazolone Analogues Containing Phosphorus and Their Reaction with Aldehydes[J]. Chem. J. Chinese Universities, 2000, 21(10): 1510.

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Studies of Quinazolone Analogues Containing Phosphorus and Their Reaction with Aldehydes

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