Chem. J. Chinese Universities ›› 1999, Vol. 20 ›› Issue (S1): 280.
• Chromatography and Separation Sciences • Previous Articles Next Articles
RUAN Yuan-Ping, HUANG Pei-Qiang, GAO Jing-Xing
Online:
Published:
Supported by:
Project supported by the NSF of China.
Abstract:
Many enantiomeric N,β,γ-substituted-γ-lactams are important intermediates for the asymmetric synthesis of biologically active alkaloids and >β-hydroxy-γ-amino acids. In this study,three N,β,γ-substituted-lactams,i.e. trans-l-benzyl-4-benzyloxy-5-methyl-2-pyrrolidone (1), trans-l-benzyl-4-hydroxy-5-methyl-2-pyrrolidone (2) and 3-acetyloxy-1-phenyl-pyrrolidine-2,5-dione (3), were synthesized in both racemic and optically active form in our laboratary. This paper reports the chromatographic resolution of these γ-lactams by HPLC on Chiralcel OB column (25 cm×4.6 mm I.D.).The results are showed in Table 1.
TrendMD:
RUAN Yuan-Ping, HUANG Pei-Qiang, GAO Jing-Xing. Enantiomeric Resolution of N,β,γ-trisubstituted-y-Lactams by HPLC on Chiralcel OB Column[J]. Chem. J. Chinese Universities, 1999, 20(S1): 280.
0 / / Recommend
Add to citation manager EndNote|Ris|BibTeX
URL: http://www.cjcu.jlu.edu.cn/EN/
http://www.cjcu.jlu.edu.cn/EN/Y1999/V20/IS1/280