Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (S1): 42.
• Organic Synthesis Chemistry • Previous Articles Next Articles
DAI Wei-Min, LEE Mavis Yuk Ha
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Abstract: Enediynes are a novel class of naturally occurring antitumor antibiotics capable of causing DNA strand cleavage by hydrogen atom abstraction from the deoxyribose backbone. During the past decade, numerous synthetic methods have been developed to synthesize the naturally occurring and the "designed" enediynes for biomedical studies. Recently, we have succeeded in assembling the cis-enediynes 2 by a novel and high-yielding allylic rearrangement under mild reaction conditions (Eq 1).1-3 This methodology has been used to synthesize a 10-membered ring enediyne3 which exhibits DNA cleavage activity.
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DAI Wei-Min, LEE Mavis Yuk Ha. Regioselective Formation of Enediynes via Intramolecular Trapping of Allylic Cations[J]. Chem. J. Chinese Universities, 1998, 19(S1): 42.
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