Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (S1): 33.
• Organic Synthesis Chemistry • Previous Articles Next Articles
Long-Chih Hwang
Online:
Published:
Abstract: A facile ring closure reaction with the N-l nitrogen of the 1,2,4-triazine ring occurs when 3-amino-6-hydrazino-1,2,4-triazin-5-one(1) is refluxed in either acid, orthoester/dimethylformamide, carbon disulfide, cyanogen bromide or nitrous acid. 3-amino-2-benzyl-6-hydrazino-1,2,4-triazin-5-one(2), containing the benzyl group on the 2-position of 1, can not be cyclized under the above reaction conditions except refluxed with carbon disulfide in pyridine-water(1:1), which will pass through a novel rearrangement cyclization to afford a bicycloheterocyclic compound,6-amino-3-benzylmercapto-1,2,4-triazolo[3,4-f][l,2,4]triazin-8(7H)-one(3). The mechanisms of their ring closure and rearrangement cyclization will be presented in detail.
TrendMD:
Long-Chih Hwang. A Novel Rearrangement Cyclization of 3-Amino-2-benzyl-6-hydrazino-1,2,4-triazin-5-one[J]. Chem. J. Chinese Universities, 1998, 19(S1): 33.
0 / / Recommend
Add to citation manager EndNote|Ris|BibTeX
URL: http://www.cjcu.jlu.edu.cn/EN/
http://www.cjcu.jlu.edu.cn/EN/Y1998/V19/IS1/33