Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (S1): 174.
• Organic Synthesis Chemistry • Previous Articles Next Articles
Hai Huang, Jinpei Cheng, Xiaohu Gao, Linjing Mu, Xubo Hu
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Abstract: As a class of peptide series, cyclic peptides have aroused great interest in the past few years. They are found to possess many biological functions such as membrane transport, antibiotics, toxins, hormones and so on1. Similar to the well-known macrocyclic compounds such as the crown ethers, cyclodextrins and calix arenes, they are found to be good host molecules as well in recognizing ions and small molecules2. Recently, much progress has been made on the synthesis of conformational constrained cyclopeptides in this laboratory. Because introducing a rigid subunit to the backbone of cyclic peptides can largely reduce their, conformational complications and enhance their recognition affinities, Ranganathan3 and Cheng4,5 and co-workers have synthesized some series of cyclic peptides analogues containing adamantane and benzene, respectively. These pseudocyclopeptides all showed good affinity to form complexes with ions and small molecules.
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Hai Huang, Jinpei Cheng, Xiaohu Gao, Linjing Mu, Xubo Hu. Synthesis of a New Conformational Constrained Cyclic Peptide Containing Pyridine and Cystine[J]. Chem. J. Chinese Universities, 1998, 19(S1): 174.
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http://www.cjcu.jlu.edu.cn/EN/Y1998/V19/IS1/174