Abstract: New structural liponucleoside prodrugs were prepared in which 5-benzoyladenosine was covalently attached to five and six-membered cyclic phospholipids. In the strategy for the synthesis, hexaethyl phosphorous triamide, activated by a catalytic amount of iodine, was used as the phosphorylating reagent in a one-pot reaction resulting in a number of phospholipid-adenosine conjugates.

Key words: 5-Benzoyladenosine, Cyclic glycerophospholipid, Conjugates, Hexaethylphosphorous triamide, Diastereoisomers