Studies on Voltammetric Behaviour and Reaction Mechanism of Bleomycin

Chem. J. Chinese Universities ›› 1997, Vol. 18 ›› Issue (1): 37.

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Studies on Voltammetric Behaviour and Reaction Mechanism of Bleomycin

LI Qi-Long, TAN Xue-Cai, HU Jin-Bo

Department of Chemistry Beijing Normal University, Beijing, 100875

Received:1996-01-05 Online:1997-01-24 Published:1997-01-24

Abstract

Abstract: In 0.05mol/L H₂SO₄ solution, two reductive peaks P₁ and P₂ of bleomycin A5were obtained.The peak potentials E_p₁, and E_p₂ are -0.83 Vand - 1.09 V(vs., Ag/AgCl),respectively.The voltammetrlc behaviour and reaction mechanism of bleomycin A₅, have been studied by means of linear sweep and cyclic voltammetry, NPP, ACpolarography and UVspectrophotometry.The experiments have proved that P₁ is irreversible adsorption wave,which involves two electrons process for the reduction of 3, 4(N = C) group in pyrimidine cyclic of bleomycin A₅.P₂ is also the irreversible adsorption wave, which involves further re-duction of pyrimidine cycle and catalyt1c hydrogen wave.

Key words: Bleomycin, Voltammetric behaviour, Adsorptive wave, Catalytic hydrogen wave

TrendMD:

LI Qi-Long, TAN Xue-Cai, HU Jin-Bo . Studies on Voltammetric Behaviour and Reaction Mechanism of Bleomycin[J]. Chem. J. Chinese Universities, 1997, 18(1): 37.

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Studies on Voltammetric Behaviour and Reaction Mechanism of Bleomycin

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