CJCU

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (3): 399.

• Articles • Previous Articles     Next Articles

Studies on Semisynthetic Cephalosporins and Penicilins Derivaties

ZHANG Zi-Yi1, YANG Feng-Ke1, GUAN Zuo-Wu2, HAO Chao-Qing3   

  1. 1. Department of Chemistry, National Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000;
    2. Institute of Applied Pharmacy, Beijing Medical University;
    3. Enterprise Group Company of Baiyunshan, Guangzhou
  • Received:1994-04-29 Revised:1994-10-07 Online:1995-03-24 Published:1995-03-24

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Abstract: Nine derivatives of 7β-(5-aryl-2H-tetrazolylacetamido) cephalosporins were synthesized by acylation of 7β-amino group of 7-ACA,7-ADCA with 5-aryl-2H-tetrazolyacetyl chlorides. In the same way,two new 7β(2-phenyl-4-quinolincarboxamido) cephalosporins and two new 6β-acyl-amino penicillins derivatvies were ohtained. Isolation and purification of the thirteen compounds were ftilfliled with Sephadex G-15 column chromatography andcentrifugal-TLC technique. The structures of new compounds were confirmed by elementary analysis,IR and 1HNMR.

Key words: Cephalosporins, Penicillins, Semisynthese, Centrifugal-TLC

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