Studies on Solid State Condesation Reaction of Aromatic Aldehydes and 3-Methyl-1-phenyl-5-pyrazolone

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (12): 1903.

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Studies on Solid State Condesation Reaction of Aromatic Aldehydes and 3-Methyl-1-phenyl-5-pyrazolone

LI Xiao-Liu^1,2, MA Hong^1,2, WANG Yong-Mei^1,2, MENG Ji-Ben^1,2

1. Department of Chemistry, Nankai University, Tianjin, 300071

Received:1994-12-01 Revised:1995-05-28 Online:1995-12-24 Published:1995-12-24

Abstract

Abstract: In this paper,the condensation reactions of substituted benzaldehydes with 3 methyl-1-phenyl-5-pyrazolone at room temperature and with Lewis acid cataly;is in solid state and in melted state were investigated, and two products,4,4'-arylidene-bis-(3-methyl-1-phenyl-5-pyrazolone) 2 and 4-arylidene-3-methyl-1-phenyl-5-pyrazolone l ,were prepared in high yields respectively.This solid state condensation, which had highly reactive selectivity and efficiency, might be a feasible synthetic method. In solution the bis-pyrazolone products 2 would be inverted into the mono-pyrazolone products 1 and pyrazolone,and the equilibrium of the interconversion between the two products 1 and 2 was reached gradually。In solid state the products 2 existed in enolic form, and could coordinated with copper ion easily.

Key words: Aromatic aldehyde, 3-Methyl-1-pheny1-5-pyrazolone, Solid state condensation

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LI Xiao-Liu, MA Hong, WANG Yong-Mei, MENG Ji-Ben. Studies on Solid State Condesation Reaction of Aromatic Aldehydes and 3-Methyl-1-phenyl-5-pyrazolone[J]. Chem. J. Chinese Universities, 1995, 16(12): 1903.

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Studies on Solid State Condesation Reaction of Aromatic Aldehydes and 3-Methyl-1-phenyl-5-pyrazolone

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