Abstract: Isochromano-[4,3-b] quinoline(2) and 9,10-methylenedioxyisochromano-[4,3-b] quino-line (3) are obtained, respectively, by condensing isochromanone (1) with o-aminobenzaldehyde and o-amino piperonal in the presence of sodium ethoxide. The new derivatives of 7-carboxyisochromano [4,3-b] quinoline (4a～e) are obtained by the reaction of (1) with isatins in a satisfactory yield. Es-terification of (4c) can be transformed into (5) which has a new cinchophen-like structure. Compound (4a) and (5) show a good antiphlogistic activity.

Key words: Isochroma-4-one, 7-Carboxyisochromano-[4,3-b] quinoline, Antiphlogistic activity