Chem. J. Chinese Universities ›› 1989, Vol. 10 ›› Issue (6): 650.

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Stereoselective Synthesis of3,5-Cyclo-Pregnane-6- Methoxyl-20-S-22-Aldehyde

Liu Xing ping1, Li Yulin1, Liang Xiaolian2   

  1. 1. Institute of Organic Chemistry, Lanzhou University, Lanzhou;
    2. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing
  • Received:1987-11-24 Online:1989-06-24 Published:1989-06-24

Abstract: The stereoselective synthesis of 3,5-cyclo-pregnane-6-methoxyl-20-S-22-aldehyde(7),which is the key intermediate of the synthesis of brassinolide(1) and its analogous, was carried out with diosgenin as starting material. In this reaction the e,e is 86.2%.

Key words: Brassinolide, Stereoselective synthesis, Diosgenin, 20-S-22-steroidal aldehyde

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