Chem. J. Chinese Universities ›› 1989, Vol. 10 ›› Issue (5): 549.
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Xu Cheng, Zhang Lihe
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Abstract: 2'-O-Tosyladenosine( Ⅰ ) was treated with n-C4H9OP(N(C2H5)2)2 in the presence of tetrazole to give n-butyl 2' -O-tosyladenosine 3', 5'-cyclo-phosphite (Ⅱa).The reaction occurred stereospecifically, and only one diastere-omer was obtained. When this reaction was carried out in the absence of tetrazole, the diastereomers Ⅱa and Ⅱb were isolated in a ratio of 4:1.
Key words: Cyclophosphorylation, n-Butyl 2'-O-tosyladenosine 3', 5'-cyclopho- sphite
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Xu Cheng, Zhang Lihe . Stereochemistry in Cyclophosphorylation of Nucleosides[J]. Chem. J. Chinese Universities, 1989, 10(5): 549.
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