Abstract:

Mannich reaction was carried out directly between arylatnine hydrochloride, 37% formaldehyde and alkylarylketone, methylalkylketone or cycloke-tone by the following method: To arylamine dissolved in ethyl alcohol, a solution of ethanolic-HCl was added. Without separating the arylamine hydrochloride which settled out readily, a mixture of 37% formaldehyde and appropriate ketone was added, and the mixture thus obtained was allowed to stand a few hours or over night at room temperature. β-Arylaminoketone hydrochloride which crystallized out during this period was separated and worked up. This is a new method for the direct synthesis of β-arylaminoketones through Mannich reaction. The yields were satisfactory.