Chem. J. Chinese Universities ›› 2025, Vol. 46 ›› Issue (1): 20240334.doi: 10.7503/cjcu20240334

• Article • Previous Articles     Next Articles

Synthesis and Antibacterial Efficacy of Cationic Polypeptides

DUAN Yuxiu1,2, WAN Pengqi2, GAOGUO Wenlie2, ZHANG Wenlong2, DENG Mingxiao1(), XIAO Chunsheng2()   

  1. 1.Faculty of Chemistry,Northeast Normal University,Changchun 130024,China
    2.Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
  • Received:2024-07-03 Online:2025-01-10 Published:2024-08-19
  • Contact: DENG Mingxiao, XIAO Chunsheng E-mail:dengmx330@nenu.edu.cn;xiaocs@ciac.ac.cn
  • Supported by:
    the National Science Fund for Excellent Young Scholars of China(52222307);the Youth Growth Technology Project of Jilin Provincial Department of Science and Technology, China(20230508153RC)

Abstract:

A series of cationic poly(α-amino acid)s(PALGn) materials with different side group structures was synthesized. The synthesized cationic poly(α-amino acid)s exhibited certain antibacterial activity in vitro. Among them, poly(γ-allyl-L-glutamate)20-butyl1(PALG20-Bu1) with the optimal ratio of cationic/hydrophobic group ratio showed the best antibacterial ability, with a minimum inhibitory concentration(MIC) of 12.5 μg/mL against Staphylococcus aureusS. aureus) and Escherichia coliE. coli.). Further mechanistic studies indicated that PALG20-Bu1 could effectively disrupt the integrity of bacterial cell membranes, leading to bacterial death. Due to this unique antibacte-rial mechanism, PALG20-Bu1 exhibited rapid bactericidal kinetics. In summary, this work proposes a promising strategy for the treatment of clinical bacterial infections.

Key words: Bacterial infection, Bacterial resistance, Poly(α-amino acid)s, Antibacterial polymer

CLC Number: 

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