Studies on Double Mannich Reaction of 3-Aryl-5-mercapto-1, 2, 4-triazoles

Abstract

Abstract: In this paper, thirteen new 3, 5-disubstltuted tetrahydro-s-triazolo [3'4-b][1'3,5]thiadiazines were prepared by double Mannich reaction in the presence of HCl-ethanol so-lution, arylamine-HCl and 37% aqueous formaldehyde solution or the condensation productof arylamine and para formaldehyde were reacted with 3-aryl-5-mercapto-1, 2, 4-triazole toform the title compounds at 45-65℃.The structure of these compounds were characterizedby elementary analysis, IR, ¹H NMRand MS.Their antibactericidal activity against E.Col-i, B-Subtilis and S.Aureus were tested.

Key words: 3-Aryl-5-mercapto-1,2,4-triazoles,3,5-Disubstituted tetrahydro-s-triazoio[3,4-b][1,5]thiadiazine, Mannich base, Biological activity

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WANG Zhong-Yi, YOU Tian-Pa, SHI Hai-Jian, SHI Hao-Xin. Studies on Double Mannich Reaction of 3-Aryl-5-mercapto-1, 2, 4-triazoles[J]. Chem. J. Chinese Universities, 1997, 18(4): 550.

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Studies on Double Mannich Reaction of 3-Aryl-5-mercapto-1, 2, 4-triazoles

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