Chem. J. Chinese Universities ›› 2001, Vol. 22 ›› Issue (4): 601.
• Articles • Previous Articles Next Articles
LIU Da-Xue, WANG Quan, ZHANG Li-Chen, DA Chao-Shan, WANG Rui
Received:
Online:
Published:
Abstract: Aseries of aromatic cyanohydrins and their Osilyl ethers have been synthesized by trimethylsilylcyanation of aromatic aldehydes using a catalyst generated in situ from optically active R-(+)-1,1'-2-bisnaphthol with n-butyl lithium. Mandelonitrile was prepared in an isolated yield 70% with more than e.e.=60%. The effect of solvents and the amount of catalyst on enantioselectivity was also investigated.
Key words: R (+)-1,1'-2-Bisnaphthol, Enantioselective synthesis, Cyanotrimethylsilane, Aromatic cyanohydrins
CLC Number:
O624
TrendMD:
LIU Da-Xue, WANG Quan, ZHANG Li-Chen, DA Chao-Shan, WANG Rui . Trimethylsilylcyanation of Aromatic Aldehydes Catalyzed by BINOL-Li Salt[J]. Chem. J. Chinese Universities, 2001, 22(4): 601.
0 / / Recommend
Add to citation manager EndNote|Ris|BibTeX
URL: http://www.cjcu.jlu.edu.cn/EN/
http://www.cjcu.jlu.edu.cn/EN/Y2001/V22/I4/601
