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Chem. J. Chinese Universities

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Differential Expressed Profile of Proteins in Normal Tissue and Pancreatic Cancer Using Proteomic Approaches

JIN Hong1,2, DI Yang3, CHEN Yao-Hui2, FU De-Liang3*, YANG Peng-Yuan1,2*   

    1. Department of Chemistry, Fudan University, Shanghai 200433, China;
    2. Institute of Biomedical Science, Fudan University, Shanghai 200032, China;
    3. Affiliated Huashan Hospital, Fudan University, Shanghai 200030, China
  • Received:2008-04-01 Revised:1900-01-01 Online:2009-02-10 Published:2009-02-10
  • Contact: FU De-Liang

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Abstract: The pancreatic cancer is one of highly malignant tumor with high morbidity rate in recent years disease incidence rate constant rise. Due its difficulty of early diagnosis, and the deep hideaway position, the cure rate and 5 years survival rate for this disease is very low. The pathogenesis of pancreatic cancer is still unknown. In this study pancreatic cancer and normal tissue(tissue nearby cancer) were used to run differential protein expression profile via 2DE and MALDI-TOF-MS-MS. Among 30 differential expressed proteins, 24 proteins are identified. 15 proteins in pancreatic cancer are up-regulated, 9 proteins are down-regulated. These proteins are probably correlated with the causes of disease and can eventually become disease biomarker and treatment target protein.

Key words: Pancreatic cancer, Differential protein expression profile, Two-dimensional gel electrophoresis, Bio-MS

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