A Study of the Influence of Cephalosporins on the Microbial Activity of E.coli by Microcalorimetry

Chem. J. Chinese Universities

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A Study of the Influence of Cephalosporins on the Microbial Activity of E.coli by Microcalorimetry

YANG Li-Ni^1,2, SUN Li-Xian¹, XU Fen¹*, ZHAO Zong-Bao³, LIANG Jian-Guo⁴

1. Materials and Thermochemistry Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;
2. Graduate University of Chinese Academy of Sciences, Beijing 100049, China;
3. Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;
4. Hunan Institute of Drug Detection, Changsha 410001, China

Received:2007-11-27 Revised:1900-01-01 Online:2008-07-10 Published:2008-07-10
Contact: XU Fen

Abstract

Abstract: The effects of Cefoperazone Sodium(CFZ) and Cefoperazone Sodium & Sulbactam Sodium for injection(CFZ-SBT) on the metabolism of Escherichia coli(E.coli) DH5α were studied by microcalorimetry. The microbial activity was recorded as power-time curves through an ampoule method with a TAM air isothermal microcalorimeter at 37 ℃. The parameters such as the growth rate constant(k), inhibitory ratio(I), the maximum power output(P_m) and the time(t_m) corresponding to the maximum power output were obtained. The lethal doses of CFZ and CFZ-SBT were calculated as 0.1 and 0.25 μg/mL, respectively. Moreover, according to the relationship between k, P_m, t_m and c, the conclusion could be made that the CFZ-SBT cannot improve the inhibitory effect on E.coli DH5α in comparison with the CFZ.

Key words: Microcalorimetry, Inhibition fuction, Cephalosporin, E.coli DH5α

CLC Number:

O642.3

TrendMD:

YANG Li-Ni^1,2, SUN Li-Xian¹, XU Fen¹*, ZHAO Zong-Bao³, LIANG Jian-Guo⁴. A Study of the Influence of Cephalosporins on the Microbial Activity of E.coli by Microcalorimetry[J]. Chem. J. Chinese Universities, doi: .

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A Study of the Influence of Cephalosporins on the Microbial Activity of E.coli by Microcalorimetry

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