CJCU

Chem. J. Chinese Universities ›› 1997, Vol. 18 ›› Issue (5): 671.

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Electrochemistry Characteristics of Adriamycin-Fe(Ⅲ) Complex and Its Interaction with DNA

WANG Hong-Fei, YANG Pin, LI Qing-Shan, WU Qiang   

  1. Department of Chemistry, Nanjing University, State Key Lab.of Coordination Chemistry, Nanjing, 210093, Institute of Molecular Science, Shanxi University, Taiyuan, 030006
  • Received:1996-04-16 Online:1997-05-24 Published:1997-05-24

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Abstract: Electrochemistry characteristics of adriamycin-Fe(Ⅲ) complex was studied by the methods of osillopolarograph and cyclic voltammetry.At physiological pH, Fe (Ⅲ) binds with ADMto form a complex of 2: 1 stoichiometry.ADMwas reduced at a more negative potential when it was complexed with Fe(Ⅲ), which is close related to the low cardiac toxicity of the complex.The interaction model of ADM-Fe(Ⅲ) complex with DNAwas studied by the methods of spectroscopy, electrochemlstry and electrophoresis.The complex preserves the DNAintercalation characteristics, and binds to DNAto form a ternary complex composed of DNA, Fe(Ⅲ) and ADM.

Key words: Adriamycin, Fe(Ⅲ) complex, Cardiac toxicity, DNA damage

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