乏氧激活化疗药物AQ4N与碳点自组装用于化疗联合声动力治疗肿瘤

庞娥, 唐垣钰, 赵少静, 程强, 王晨, 陈健敏, 蓝敏焕

Hypoxia Activated Chemotherapy Drug AQ4N and Carbon Dots Self-assembly for Chemotherapy Combined with Sonodynamic Therapy of Tumors

PANG E, TANG Yuanyu, ZHAO Shaojing, CHENG Qiang, WANG Chen, CHEN Jianmin, LAN Minhuan

Fig.4 In vivo animal experiments in different treatment groups （A） Fluorescence imaging picture of mice after intratumoral injection of CDs@AQ4N（L： left tumor， R： right tumor； Ex=600 nm， Em=670 nm）； （B—F） variation of tumor volume of different treatment groups； （G） photographs of tumors of different treatment groups after the end of treatment（n=5）； （H） variation of body weight of mice in different treatment groups； tumor tissue of mice in different treatment groups H&E（I）， Ki67（J）， TUNEL（K） and HIF-1α（L） section staining images.