Abstract: Thirteen novel substituted trans-4-amino-3, 4-dihydro-2, 2-dimethyl-2H-1-ben zopyran-3-ols have been prepared and evaluated for their relaxant activity in the anaesthetized normotensive sprague-dawley rats.The synthetic route to these compounds involves the conversion of 2H-1-benzopyrans to bromohydrins, followed by conversion to epoxides,which were ring opened with appropriate amines or acylhydrazines.Some of these compounds showed marked vasodilator and antihypertensive activities.

Key words: Potassium channel openers, Benzopyrans, Cardiovascular activity