Chem. J. Chinese Universities ›› 2021, Vol. 42 ›› Issue (3): 725.doi: 10.7503/cjcu20200640

• Analytical Chemistry • Previous Articles     Next Articles

Development of Small Animals in vivo Fluorescence-photothermal Dual Mode Imaging System

CHEN Hongda1,2, ZHANG Hua1(), WANG Zhenxin1,2   

  1. 1.State Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
    2.School of Applied Chemical Engineering,University of Science and Technology of China,Hefei 230026,China
  • Received:2020-09-01 Online:2021-03-10 Published:2021-03-08
  • Contact: ZHANG Hua E-mail:zhanghua@ciac.ac.cn
  • Supported by:
    ? Supported by the National Natural Science Foundation of China(21775145);the Jilin Provincial Science and Tech-nology Department Foundation, China(20200404192YY)

Abstract:

This study reports a small animal in vivo fluorescence-photothermal dual-mode imaging system, which has dual functions of fluorescence imaging and thermal imaging. The system has high imaging sensiti- vity, fast acquisition speed(≤51 frame/s), and large tissue penetration depth(near infrared fluorescence up to 10 mm during imaging), and a thermal imaging resolution of 0.1 ℃. The system can not only achieve fluorescence imaging of small animal subcutaneous tumors and deep tissues/organs, but also integrates thermal imaging to monitor temperature changes in photothermal therapy in real time, as well as the controlled release process of drugs to achieve precise treatment.

Key words: Fluorescence imaging, Thermal imaging, Drug controlled release, Diagnosis and treatment integration

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